The objectives of this research were to 1) develop computer-assisted instruction (CAI) for the flipped classroom, 2) evaluate the effectiveness of the developed CAI in the flipped classroom, 3) compare students’ achievement before and after studying with the CAI in the flipped classroom, and 4) ascertain students’ satisfaction. The study’s objectives were accomplished with the use of a mixed-methods approach and an integrated quasi-experimental methodological design. One hundred and eleven undergraduate students participated in this research. The CAl, the student achievement exam, the student outcomes evaluation form, and the satisfaction assessment form were employed as research tools in this study. The sample was created using a straightforward selection technique. The study’s results indicated that the flipped classroom’s CAI achieved an efficiency of 82.43/93.25, above the stated efficiency requirement of 80/80. At 0.05, achievement after learning increased statistically substantially as compared to before learning. Student satisfaction with the created CAI lesson was an average of 4.35, which was judged excellent, and 80% of all learner work was of high quality. For pedagogical purposes, it is critical to evaluate instructors’ competence to create instructional materials utilizing videos on their own, both in terms of teacher and student access to digital resources.