Thailand does not have a management system in place for medical cannabis; other usages are also illegal. Existing laws and regulations are century-old product of government, labeling the total life cycle of this potentially lucrative and medicinal plant as illegal in all aspects. Present political will of the coalition government, consisting of 15 parties, is facing mountains of hurdle to legalize cannabis. The infantry stage of Thailand sees no instant short-cut, but there are valuable lessons from other countries that have relaxed their cannabis use policies. This research paper aims to find out probable future scenarios that fit Thailand’s socio-economic and political context over the next 3-5 years, and a possible cannabis management model in transition. Using a qualitative approach, this research collected data using the Delphi Technique. Key informants were to choose one from three future scenarios and possible optional models of management that deem most appropriate and effective. Based upon Knight’s Social Organization concept, this paper proposes three prototype models of management which are also Pareto optimal. The management operation is to segment ‘markets’ and apply a cross subsidy to enhance research over the 3-year span so that scientific information could be generated for improved decision. Meanwhile, however, it is most imperative to establish a semi-independent task force, called New Social Organization, composed of, a widest range possible, stakeholders to implement near-term and immediate plans. Meanwhile, a legal reform is necessitated to facilitate various usages, primarily that of medical application. It is also imperative to enable a systematic support for applied research and development on cannabis—being the corner stone of management.