Chronic obstructive pulmonary disease (COPD) is systemic inflammation that is caused comorbidities such as metabolic syndrome (MetS), type 2 diabetes mellitus (type 2 DM), and cardiovascular disease. Mild cognitive impairment (MCI) has been reported as comorbidities in COPD. However, prevalence of MCI and risk factors involved MCI in COPD, especially male has been minimally reported. Almost prevalence of COPD in Thailand has found in male. Objectives: to investigate the prevalence of MCI and characteristics of MCI in male COPD. Methodology: one hundred and sixty-nine males with COPD recruited into this study between 2017-2019. They were tested the cognitive impairment using Thai version of Montreal Cognitive Assessment (MoCA). The cut point for normal cognitive function when the score is ³ 25 points. The prevalence of male with COPD was calculated. In addition, the characteristics of MCI in male COPD was analyzed. Result and Discussion: the prevalence of MCI in male with COPD was 77.51%. Total score of MoCA of COPD with and without MCI were 18.60±4.34 and 26.21±1.49, respectively (p=0.01). Domains of memory, visuospatial/executive, attention, language and abstract were decreased in COPD with MCI compared with non-MCI, p<0.05. Risk factors of MCI in male COPD might be involved with age, education, smoking, and exacerbation. Conclusions: cognitive impairment was one comorbidities of male COPD and type of MCI in male COPD was the amnestic MCI multiple domains.