The objectives of the study were (1) to investigate 12^th grades’ media literacy after learning Chemistry subject on the topic of biomolecules using the Science-Technology-Society approach, and (2) to study the learning management this topic using the Science-Technology-Society approach to support students’ media literacy. The study purposively selected 42 students studying 12^th grade in Math and Science program at a state school in Pathum Thani, Thailand. The research instruments were four lesson plans designed following the Science-Technology-Society approach, the pre and post-test about media literacy, worksheets about biomolecules in social media, and recordings after using each lesson plan. For data statistically analysis, the researcher used mean ( ), percentage, standard deviation (S.D.) and normalization gain <g>.

           The findings showed that the students’ media literacy increased after learning Chemistry subject on the topic of biomolecules using the Science-Technology-Society approach. To extend, 34 students (80.95%) were in the medium gain of the increasing (<g> between 0.30 and 0.70), and 8 students (19.05%) were in the low gain (<g> less than 0.30). Provides the scores were examined in the media literacy indicator (access, analysis, evaluation, and creation), there were increases in each indicator. The processes for management of Chemistry subject on the topic of biomolecules using the Science-Technology-Society approach to support students’ media literacy were using an article or media relating to students’ living, activating and advising the students to question, analyze and interpret the content of media, and group discussing.