Objectives: Kidney transplantation is currently widely accepted owing to improving quality and length of life. However, the kidney transplant recipient has to receive long-term immunosuppressive therapy in order to prevent kidney transplant rejection, it declines the immunology system. Different oral and dental problems also increase in these patients, which mostly develop as a consequence of side effects and drug interaction during immunotherapy. This study aims to determine oral soft tissue lesions and plaque index in kidney transplant recipients. Methodology: The cross-sectional study was conducted in April to October 2019. Seventy-one kidney transplant recipients were examined for oral soft tissue lesion, oral hygiene and gingival hyperplasia. Oral lesions were analyzed descriptively. Univariate and multivariate linear regression was used to assess relationship between plaque index and different variables. Result and Discussion: Oral lesions were found in 8 (11.3%) kidney transplant recipients. The most common oral lesion was oral ulcer (8.4%) followed by median rhomboid glossitis (1.4%) and fibroma (1.4%). Gingival hyperplasia was found 1.4% in the kidney transplant recipients. Multivariate linear regression revealed that plaque index was increasing by age (regression coefficient (95% confidence interval) = 0.009 (0.003-0.018); p=0.041). Conclusions: Oral lesions were found in 11.3% of kidney transplant recipients. These lesions can be related to immunosuppressive drugs, either as side effects or as a direct consequence of the patients’ immune status. Regular dental examination is necessary for early detection of oral lesion, which allows consulting in medications adjustment and stops or relieves progression of oral lesion.