As the number of older adults with diabetes increases, the number of diabetes-related complications appears to be more common among the older adults with diseases than those without diseases. The oral complication is included as well as hyposalivation. The purpose of this study was to investigate the prevalence of hyposalivation and identify the factors associated with this condition in the older adults with diabetes in the Kaengkhoi district, Saraburi province. Participants and Methods: Three hundred and seventy-seven participants aged 60 years and over who met the eligibility criteria were enrolled in this study. All participants were interviewed about general information and health information. The whole saliva was collected both in resting and stimulating conditions. Medical information and laboratory results were obtained from the hospital’s electronic records. Statistical analysis was performed to reveal the association of all factors. Result and Discussion: Among a total number of 377 participants (64.19% female, mean age 68.67±6.33 years old), the prevalence of hyposalivation was 63.40%. The median resting salivary flow rate among male and female participants who had hyposalivation (0.04 and 0.05, respectively) was lower compared to those without hyposalivation (0.17 and 0.19, respectively). The level of glycemic control, determined by HbA1C, and the presence of microalbuminuria were the only two factors associated with hyposalivation in this study. HbA1C level (HbA1C 7-8: OR=2.09; 95%CI: 1.18-3.67; p=0.002 and HbA1C >8: OR=2.39; 95%CI: 1.32-4.31; p=0.004) and presence of microalbuminuria (OR=3.41; 95%CI: 2.11-5.52; p<0.001) associated with hyposalivation. Due to the association between microalbuminuria and duration of disease, glycemic control, and other factors, the association revealed in the present study may therefore be due to changes in salivary gland function caused by poorly controlled and prolonged diabetes. Conclusions: Hyposalivation is a common complication among older adults with diabetes. Objective screening for those conditions and implementing the preventive measurements are beneficial in diabetes older adults, particularly in poorly controlled diseases and those with diabetic-related complications. Although diabetes is a chronic disease, achieving well glycemic control could reduce the various effects, including oral complications.