The study aimed to compare the remineralization in artificially caries-affected dentine restored with three different materials. The mechanical strength of dentin was used to assess remineralization effectiveness. Twenty-five human third molar teeth were prepared in class v cavities, and twenty cavities were used to simulate caries-affected dentin using the pH cycling method. Fifteen cavities, simulated as caries-affected dentin, were filled with three groups of different materials (n=5): group 1-calcium silicate cement, group 2-conventional glass ionomer cement, and group 3-resin-modified glass ionomer cement resin and immersed in artificial saliva for one week. The five demineralized cavities without restoration served as the group 4-negative control group, while the five sound cavities served as the group 5-positive control group. All specimens were cut longitudinally, and the nanoindentation test was performed on dentine at the axial wall. The data were analyzed using One-Way ANOVA and the Bonferroni method (α=0.05). All groups had a different modulus of elasticity (p<0.05) except for the negative control group, conventional glass ionomer cement, and resin-modified glass ionomer cement, which were not statistically significant. The positive control group had the highest modulus of elasticity at 18.37±1.88 MPa. Calcium silicate cement was the second at 9.68±1.21 MPa, conventional glass ionomer cement at 2.61±0.57 MPa, resin-modified glass ionomer cement at 2.36±0.25 MPa, and the negative control group at 2.11±0.35 MPa respectively. This study found that calcium silicate cement was more effective than glass ionomer cement in remineralizing human dentin.