Unintended pregnancy in Thailand at present ranks second in ASEAN (Child and Adolescent Mental Health Rajanagariadra Institute, n.d.). Unintended pregnancy occurs due to many reasons including lack of knowledge of safe sex, lack of understanding of sex, or sexual harassment. The number of unintended pregnancies in Thailand has been increasing. However, there is no space for counseling and discussion for physical and mental rehabilitation for good quality of life of women with unintended pregnancy in Thailand yet. This project, therefore, aims to develop and study space to be suitable for physical and mental rehabilitation according to the space format. The therapeutic design is used in architecture to create a sense of warmness and safety while space is used to support the current situation in Thailand. The study method is called ENO Method. The researcher employed the framework in the part of creating innovation and business to be applied such as 7 Modes, Business Model Canvas, and Sprint process to create the customer-centric mindset with the architectural design process. Architectural programming is created to propose the introduction of design guidelines by visual presentation. The objectives of this research are to study designing architectural projects for unintended pregnancies in Thailand using therapeutic design and to study and design large buildings with therapeutic design. The results revealed that therapeutic design application can encourage physical and mental rehabilitation and also support the space in the aspects of relaxation and appropriate atmosphere for space usage. The use of materials and colors creates a sense of warmness and safety, reduces stress, and gives a comfortable feeling to women with unintended pregnancies. Related project developers or government sectors can adapt the design guidelines in this research to their family planning centers in the future.