Psoriasis is an inflammatory mediated skin disease with significant physical and psychological distress. As there are conflicting data from published literature on the association between psoriasis and pregnancy; therefore, the researchers hypothesized that the dysregulation of the immune system in psoriasis will result in a negative impact regarding fetomaternal morbidity and mortality. The primary objective of this systematic review and meta-analysis is to assess the effect of maternal psoriasis and preterm labor. The researchers searched Web of Science, PubMed, Cochrane Central Register of Controlled Trials, and SCOPUS for published articles between January 1980 and December 2020, including reference lists of relevant studies. All 1592 citations were reviewed and identified studies examining adverse pregnancy outcomes associated with psoriasis. Seventeen studies were included with a total of 44,249 pregnancies with psoriasis and 47,807,880 pregnancies without the disease. Random-effect models were used to create pool odds ratios. For women with psoriasis, a higher odd of preterm labor was founded compared with non-disease controls (10 studies: OR 1.28, 95%CI 1.14-1.44). The results of this study confirmed that psoriasis is a risk factor for preterm labor.