This article aims to demonstrate the contexts relating to the concepts of Blues melody and harmony, which include blues notes, sentence structure, chord progression, and reaction. These contexts are indispensable in demonstrating the significance of the blues. They are also materials that many composers employ in their creation of music in another genre, such as in Jazz blues. Blues is, therefore, an epitome of a rich musical tradition, elevated as a precious music culture, even though their original creators, those who suffered from slave trading and inhumane treatment, have no academic background in music.