Gingivitis is one of the most common oral diseases that can occur in every individual. Normally, mechanical and chemical plaque controls are used to remove the plaque. Chemical plaque control like mouthwash is widely used for adjunctive therapy. Chlorhexidine mouthwash is the gold standard mouthwash used in aiding the treatment of periodontitis but it still has undesirable side effects. Andrographis paniculata mouthwash becomes an alternative due to its properties. The objective of this study is to compare the gingivitis control effects of Andrographis paniculata with a commercially available chlorhexidine gluconate mouthwash. Forty healthy subjects aged 18-30 years old were randomly divided into two groups of 20 patients each; Group A Chlorhexidine mouthwash and Group B Andrographis paniculata mouthwash. All subjects received oral hygiene instructions, scaling, and prophylaxis. The collected data comprised gingival index (GI) at baseline and after using the designated mouthwash for 3 weeks. The results had shown that the baseline data are not significantly different from each other. Both types of mouthwash can reduce the GI but not significantly different from the baseline and each other. In conclusion, Andrographis paniculata can be used as an adjunctive to mechanical oral hygiene procedures and as an alternative to chlorhexidine, especially in patients whose self-performed oral hygiene may be limited.