Androgenic alopecia (AGA) is a non-scarring hair loss problem caused by multiple etiologies, including genetic, hormone androgen, and micro-inflammation of the perifollicular area. The standard treatment for AGA is topical minoxidil and systemic 5α-reductase inhibitor which is still limited by its efficacy and side effects. A 1550-nm erbium glass laser is one of the effective treatment modalities for AGA that show a satisfactory result. However, the mechanism of how this laser stimulates hair regrowth is still unclear. Macrophages have been identified as an important role in hair cycling. The authors histologically evaluated changes in macrophage expression in balding scalp areas of subjects with an improvement, comparing pre and post-laser treatment to identify the mechanism of laser-induced hair growth. A total of 12 samples were stained with CD68 and evaluated by an experienced pathologist. Nonetheless, the authors failed to demonstrate any of these alterations. In conclusion, to diminish the negative finding, it is suggested to perform optimal laser parameters and evaluate the right tissue plane.