RSUSSH 2020
IN20-247 The effect of probiotics supplementation on inflammatory markers in non-communicable disease subjects: A Preliminary report
Presenter: Periyanaina Kesika
Chiang Mai University, Thailand
Abstract
This research investigated the effects of probiotics on inflammatory markers in subjects with non-communicable disease. Ten adults with symptoms of chronic non-communicable diseases and abnormal intestinal permeability were involved in this experiment. After initial screening, the ten subjects were randomly divided into two groups as placebo and probiotic group (Bifidobacterium breve 50 x 109 CFU per day). Each group had received the respective supplementation once per day for 12 weeks. Their blood samples were collected at the baseline and after the treatment. The study was conducted upon the subjects to investigate the parameters associated with the inflammation markers such as inflammatory cytokines (IL-6 and IL-1β) and anti-inflammatory cytokines (IL-10). All parameters were analyzed before and after taking the probiotics for 12 weeks. The inflammatory cytokines levels had significantly reduced, of which the levels of IL-6 and IL-1β had reduced from 10.78 and 6.32 to 8.60 and 5.96 pg/ml after the treatment in the probiotic group, comparing the placebo. The anti-inflammatory cytokine levels had significantly increased, of which the levels of IL-10 had increased from 1.26 to 9.21pg/ml, respectively, as compared to the control. This study recommended that probiotics play a vital role in inflammatory regulation in subjects with chronic non-communicable diseases.
Citation format:
Chaiyavat, C., Periyanaina, K., Sasithorn, S., Bhagavathi Sundaram, S., Narissara, L., Sartjin, P., Nanticha, K., & Phakkharawat, S.. (2020). The effect of probiotics supplementation on inflammatory markers in non-communicable disease subjects: A Preliminary report. Proceeding in RSU International Research Conference, May 1, 2020. Pathum Thani, Thailand.QUESTIONS & ANSWERS
In your opinion, how probiotic can reduce the inflammatory cytokines level and promote the level of anti-inflammatory cytokines?
What is the mechanism of probiotics for lowering inflammatory cytokines?
Dear Panan,
the supplementation of probiotic could improve the gut microbiota and reduced the release of bacterial compounds like LPS and other cellular debris, which are the stimulators of local and systemic inflammatory reaction. So the reduction of microbial inducer leads to the lowering of pro inflammatory marker release. Then our body works against the existing damages via producing anti-inflammatory markers.
Further studies are needed to confirm the proposed mechanism of probiotic action.
Thank you
Dear Yusuf,
the supplementation of probiotic could improve the gut microbiota and reduced the release of bacterial compounds like LPS and other cellular debris, which are the stimulators of local and systemic inflammatory reaction. So the reduction of microbial inducer leads to the lowering of pro inflammatory marker release. Then our body works against the existing damages via producing anti-inflammatory markers.
Further studies are needed to confirm the proposed mechanism of probiotic action.
Thank you
What kind of probiotics and dosage you recommend to consume for lower inflammatory cytokines?
Dear Yusuf
we now working in the formulation of better probiotic supplements to control the inflammation related health issues. Further studies are underway, so at this stage I could not recommend any probiotics for the consumption. Once the detailed clinical studies have been done, we will publish the results and according to the regulations we may develop the consumer products.
thank you for your interest