RSUSSH 2020
IN20-168 The efficacy of 1550-nm fractional Erbium–glass laser in androgenic alopecia: A systematic review and meta-analysis
Presenter: Sopheavakneary Khun
Thammasat University, Thailand
Abstract
This systematic review and meta-analysis aimed to evaluate the efficacy of 1550-nm erbium glass fractional laser in treating androgenetic alopecia in both men and women for improving hair density and hair shaft diameter. A systematic review was conducted. PubMed, Embase, and Cochrane were searched up to December 2019, with no lower limit on the year. We included prospective trial, semi-experimental, randomize control trial, interventional study on human study. Four articles including 278 participants which treated with 1550-nm erbium glass laser were selected for our analysis, all studies evaluated the change in hair density and hair shaft diameter. It’s found a statistically significant hair density and hair shaft diameter increased in the 1550-nm erbium glass laser group. The overall SMD regarding changes in hair density was 25.26 (95% confidence interval CI 8.62 to 41.89) the P=0.003 and the SMD heterogeneity the I2 was 98%. Whereas, the change in hair shaft diameter, the overall SMD was 2.03 (95% confidence interval CI 0.91 to 22,14) the P =0.0004 with the SMD heterogeneity I2 was 92%, suggested that this treatment provided an essential result in increasing hair shaft diameter and hair density without any harmful effect.
Citation format:
Khun, S., & Nitayavardhana, S.. (2020). The efficacy of 1550-nm fractional Erbium–glass laser in androgenic alopecia: A systematic review and meta-analysis. Proceeding in RSU International Research Conference, May 1, 2020. Pathum Thani, Thailand.QUESTIONS & ANSWERS
Can 1550-nm fractional Erbium-glass laser use in treating other types of alopecia, apart from androgenic alopecia?
Yes it can, example like alopecia areata.
Where is your presentation view?
I saw only your face?
What is the mechanism of f1550-nm fractional Erbium–glass laser in androgenic alopecia treatment ?
First of all, i would like to say thank you for interested to my research.
Dear visitor @Tasanee Pujannon
Yes, 1550-nm erbium glass fractional laser not only can be treated with androgenic alopecia but aslo can be use as a good treatment optio for alopecia areata as well.
Dear visitor, @suparuj lueangarun
I would like to apologized for my inconvenience for the slide due to the technical issue.
The exact mechanism of 1550-nm erbium glass laser is still not well understood but it could be a number of possible laser irradiation physiological mechanisms can play a role in improving hair growth, including increased blood flow, promotion of anagen hair growth, and enhanced transformaion of the telogen to anagen phase.
The fractional erbium-glass laser wounding induced an increment of blood flow, cytokines, and growth factor changes, many of molecular manipulators in wound healing, including members of the FGF family, EGF, IGFs, HGF, TGF-b, VEGF, NGF, and interleukins, are also known as key factors of hair growth and the hair cycle. So, the changes in cytokines and growth factors might have an important position in the pathogenesis of 1550-nm fractional erbium-glass laser–induced hair growth stimulation and hair cycle progress, especially, Wnt, B-catenin, and Lef1 signaling.
Thank you.
Which patient characteristic that you will recommend the treatment wth this laser ?
Dear visitor @Suparuj Lueanfgarun
I would recommend to both male and female of patient with the age range from 18years old who has Androgenic alopecia in very stage but base on our study shows that female has better outcome than male plus treatment from the early stage of AGA would have a better outcome that the late stage. Moreover combination treatment such as minoxidil with this treatment provide superior result than laser alone.
Best regards,
Presenter.