Objective: To study the risk factors which increase the risk of hearing loss in a patient with Streptococcus suis infection in Uttaradit hospital in Thailand, Streptococcus suis infection incline to increase constantly. Particularly in Uttaradit province which has been ranked as the second place of the chance of hearing loss.

     Methodology: A retrospective case-control study. Data was taken from medical records and audiograms of the patients who visited Uttaradit hospital between 1 January 2009 to 31 October 2019 and were first diagnosed as Streptococcus suis infection and had the evidence of auditory examination. 92 patients were chosen which divided into 38 patients who the individual has sensorineural hearing loss or mixed hearing loss as a study group and another 54 patients who the individual has no hearing loss or conductive hearing loss as a control group. By using the descriptive and analytic statistics. Results and Discussion: The results revealed that dyslipidemia and meningitis were associated with significantly increasing the chance of hearing loss 28.7 (95%CI=1.20-685.18, p=0.038) and 8.2 (95%CI=1.99-14.19, p=0.004) times, respectively. In contrast, hypertension, male and kidney disease have insignificantly increased 2.1 ( 95%CI=0. 59- 7. 80, p=0. 250) , 1. 8 ( 95%CI=0. 38- 8. 68, p=0. 457) and 1. 4 ( 95%CI=0. 30- 6. 21, p=0. 684) times, respectively. The limitation of this study is the capability to control variables and adequate sample size. Conclusions: The patients with Streptococcus suis infection and dyslipidemia and/or meningitis have increased the risk of hearing loss.