RSUSSH 2020

IN20-014 A Study on Design and Construction of Non-invasive Cholesterol Sensor

Presenter: Phuriwat Ananpatiwet
Rangsit University, Thailand

Abstract

          The objective of this project was to study on the design and construct a non-invasive cholesterol sensor based on the principle of light absorption. The design and construction of our device was composed of 4 main parts; 1) the input part consisting of two different wavelengths of LEDs for the light source, reference light, and the detector circuit; 2) the signal conditioning part consisting of current to voltage, AC amplifier and inverting amplifier circuit; 3) the processing part using a microcontroller for converting from Analog signals to digital and performing signal processing 4) the display part including Liquid Crystal Display (LCD) for displaying blood cholesterol levels in mg/dL. The result of functional testing compared with clinical blood sampling method by the Faculty of Medical Technology Rangsit University, found that the average error was 2.52%.

Keywords: Non-invasive Cholesterol Sensor; Cholesterol Sensor

Citation format:

Anupongongarch, P., Kaewgun, T., & Ananpatiwet, P.. (2020). A Study on Design and Construction of Non-invasive Cholesterol Sensor. Proceeding in RSU International Research Conference, May 1, 2020. Pathum Thani, Thailand.

QUESTIONS & ANSWERS

Dr. Phitsini Suvarnaphaet (Chairperson)

What is the precision referred to the bandwidth of the signal and what is the accuracy of this cholesterol sensor to target with the cholesterol and its reference?

Dr. Phitsini Suvarnaphaet (Chairperson)

How many cycles can be used repeatedly?

Phuriwat Ananpatiwet (Presenter)

What is the precision referred to the bandwidth of the signal?

1. We used sensor wavelength 1200 nm (+,-50 nm) which can be absorbed by blood cholesterol  (Fleming, C. P., Eckert, J., Halpern, E. F., Gardecki, J. A., & Tearney, G. J..,2013) and used a photodiode as a receiver that is suitable of the near-infrared 1200 nm.
2. We used the red light as the background of the sensor circuit. When we tested the sensor circuit, we found that the output voltage difference during absorption of the near-infrared light and the red light while two light shines through the fingertip was constant value at 2.08 V.

 What is the accuracy of this cholesterol sensor to target with the cholesterol and its reference?

The average accuracy testing of a non-invasive cholesterol sensor was 97.4% compared with the cholesterol by blood collection at the Medical Technology Clinic of Rangsit University.

How many cycles can be used repeatedly?

10 cycles 

Prof. Dr. suejit pechprasarn (Chairperson)

Why did you choose to fit the calibration curve with polynomial degree 3 rather than an exponential function?

Prof. Dr. suejit pechprasarn (Chairperson)

You showed in your results that you have higher error with the higher cholesterol group. Is there any reason to explain this effect?

 

Phuriwat Ananpatiwet (Presenter)

1. Why did you choose to fit the calibration curve with polynomial degree 3 rather than an exponential function?

Because I try in both ways but I found that the coefficient of determination of the calibration curve with polynomial degree 3 was 0.99 that was better than the exponential function.

 

2. You showed in your results that you have higher error with the higher cholesterol group. Is there any reason to explain this effect?

The higher cholesterol group has a higher error because the number of samples with high cholesterol is small. To improve this situation, future works may involve testing greater numbers of cholesterol patients, thus obtaining more representative calibration data.

Abu Hashem (Participant)

In your results, data in table 1 and adjacent graph showed that digital output has no linear relationship with concentration of cholesterol. How did you corelate this issue in your sensor to find actual concentration of cholesterol from digital output?

jaroonrut prinyakupt (Visitor)

Is five subject data cover the range of  the concentration of cholesterol? What about your plan on the data collection for the future study?

 

Nuntachai Thongpance (Visitor)

What is the factors which effect to the accuracy of the machine?

Phuriwat Ananpatiwet (Presenter)

ANSWER ABU HASHEM

1.In your results, data in table 1 and adjacent graph showed that digital output has no linear relationship with concentration of cholesterol. How did you corelate this issue in your sensor to find actual concentration of cholesterol from digital output?

The researchers used microcontroller to convert digital output to concentration of cholesterol. by using calibration equation that created from calibration graph and coded on the microcontroller.

Phuriwat Ananpatiwet (Presenter)

ANSWER JAROONRUT PRINYAKUPT

1. Is five subject data cover the range of  the concentration of cholesterol?

No, five subjects data didn’t cover the range of the concentration of cholesterol.

2.What about your plan on the data collection for the future study?

For my future study, I will collect research data by covering all level of cholesterol : low, moderate and high. In order to conduct the research sensor reliable the future research has to increase the number of samples that is sufficient and accurate according to the research methodology.

Phuriwat Ananpatiwet (Presenter)

ANSWER NUNTACHAI THONGPANCE

1. What is the factors which effect to the accuracy of the machine?

The factors that effect to the accuracy of the machine sensor are nail color, motion and posture of measurement. These factors will reduce the measure accuracy.